Publications
2023
Buyukkurt A and Harroud A. The potential of human genetics to inform statin use in multiple sclerosis. Neurology. 2023; Accepted.
Harroud A, Stridh P, McCauley JL, Saarela J, Jónsdóttir I, van den Bosch AMR, Engelenburg HJ, Beecham AH, Alfredsson L, Alikhani K, Amezcua L, Andlauer TF.M, Ban M, Barcellos LF, Barizzone N, Berge T, Berthele A, Bittner S, Blanco Y, Bos SD, Briggs FB.S, Caillier SJ, Calabresi PA, Caputo D, Carmona-Burgos DX, Cavalla P, Celius EG, Cerono G, Chinea AR, Chitnis T, Clarelli F, Comabella M, Comi G, Cotsapas C, Cree BCA, D'Alfonso S, Dardiotis E, De Jager PL, Delgado SR, Dubois B, Engel S, Esposito F, Fabis-Pedrini MJ, Filippi M, Fitzgerald KC, Gasperi C, Gomez L, Gomez R, Hadjigeorgiou G, Hamann J, Held F, Henry RG, Hillert J, Huang J, Huitinga I, Islam T, Isobe N, Jagodic M, Kermode AG, Khalil M, Kilpatrick TJ, Konidari I, Kreft KL, Lechner-Scott J, Leone M, Llufriu S, Luessi F, Madireddy L, Malhotra S, Manouchehrinia A, Manrique CP, Martinelli-Boneschi F, Martinez AC, Martinez-Maldonado V, Mascia E, Metz LM, Midaglia L, Montalban X, Oksenberg JR, Olsson T, Oturai A, Pääkkönen K, Parnell GP, Patsopoulos NA, Pericak-Vance MA, Piehl F, Rubio JP, Saiz A, Santaniello A, Santoro S, Schaefer C, Sellebjerg F, Shams H, Shchetynsky K, Silva C, Siokas V, Søndergaard HB, Sorosina M, Taylor B, Vandebergh M, Vasileiou ES, Vecchio D, Villoslada P, Voortman MM, Weiner HL, Wever D, Yong V, Stefánsson K, Hafler DA, Stewart GJ, Compston A, Zipp F, Harbo HF, Hemmer B, Goris A, Smolders J, Hauser SL, Kockum I, Sawcer SJ, Baranzini SE. Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature. 2023; Accepted.
Harroud A and Hafler D. Common genetic factors among autoimmune diseases. Science. 2023 May 5;380(6644):485-490.
Rolfes M, Harroud A, Zorn KC, Tubati A, Omura C, Kurtz K, Matloubian M, Berger A, Chiu CY, Wilson MR, Ramachandran PS. Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report. Neurology: Neuroimmunology & Neuroinflammation. 2023 Jun 20;10(5):e200121.
Dishnica N, Vuong A, Xiong L, Tan S, Kovoor J, Gupta A, Stretton B, Goh R, Harroud A, Schultz D, Malycha J, Bacchi S. Single count breath test for the evaluation of respiratory function in Myasthenia Gravis: A systematic review. Journal of Clinical Neuroscience. 2023 Jun;112:58-63.
Madike R, Muecke T, Dishnica N, Zhu L, Tan S, Kovoor J, Gupta A, Harroud A, Bersten A, Schultz D, Bacchi S. A vital parameter? Spirometry in evaluation for intensive care unit admission and intubation and ventilation for Guillain-Barré syndrome. Journal of Clinical Neuroscience. 2023 Jul;113:13-19.
Chen JS, Lamoureux AA, Shlobin NA, Elkaim LM, Wang A, Ibrahim GM, Obaid S, Harroud A, Guagagno E, Dimentberg E, Bouthilier A, Nguyen DK, Fallah A, Weil AG. Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-Resistant Epilepsy: A Systematic Review and Individual Participant Data Meta-Analysis. Epilepsia. 2023 Feb 23. doi: 10.1111/epi.17560. Epub ahead of print.
Morris JH, Soman K, Rabia Akbas R, Zhou X, Smith B, Meng EC, Huang CC, Cerono G, Schenk G, Rizk-Jackson A, Harroud A, Sanders L, Costes SV, Pico AR, Mardirossian T, Keiser M, Tang A, Hardi J, Shi Y, Israni S, Huang S, Rose PW, Nelson CA, Baranzini SE. The scalable precision medicine open knowledge engine (SPOKE): A massive knowledge graph of biomedical information. Bioinformatics. 2023 Feb 3;39(2):btad080.
Bartley CM, Ngo TT, Cadwell CR, Harroud A, Schubert RD, Alvarenga BD, Hawes IA, Zorn KC, Huynh T, Teliska LH, Kung AF, Shah S, Gelfand JM, Chow FC, Rasband MN, Dubey D, Pittock SJ, Derisi JL, Wilson MR, Pleasure SJ. Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report. Frontiers in Neurology. 2023 Jan 23;13:1102484.
2022
Zhou X, Baumann R, Gao X, Mendoza M, Singh S, Sand IK, Xia Z, Cox LM, Chitnis T, Yoon H, Moles L, Caillier SJ, Santaniello A, Ackermann G, Harroud A, Lincoln R, Gomez R, González Peña A, Digga E, Hakim DJ, Vazquez-Baeza Y, Soman K, Warto S, Humphrey G, Farez M, Gerdes LA, Oksenberg JR, Zamvil SS, Chandran S, Connick P, Otaegui D, Castillo-Triviño T, Hauser SL, Gelfand JM, Weiner HL, Hohlfeld R, Wekerle H, Graves J, Bar-Or A, Cree BAC, Correale J, Knight R, Baranzini SE. Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell. 2022; 185(19):3467–3486.
Kearns PKA, Martin SJ, Chang J, Meijboom R, York EN, Chen Y, Weaver C, Stenson A, Hafezi K, Thomson S, Freyer E, Murphy L, Harroud A, Foley P, Hunt D, McLeod M, O’Riordan J, Carod-Artal, FJ, MacDougall NJJ, Baranzini SE, Waldman AD, Connick P, Chandran S. FutureMS Cohort Profile: A Scottish Multi-Centre Inception Cohort Study of Relapsing-Remitting Multiple Sclerosis. BMJ Open. 2022 Jun 29;12(6):e058506.
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N, University of California San Francisco MS-EPIC Team, Schaefer C, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser AL, Barcellos LF, Henry RG, Oksenberg JR. Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans. Brain, 2022 Mar 7:awac092.
2021
Harroud A, Mitchell RE, Richardson TG, Morris JA, Forgetta V, Davey Smith G, Baranzini SE, Richards JB. Childhood obesity and multiple sclerosis: a Mendelian randomization study. Multiple Sclerosis Journal. 2021; 27(14):2150-2158.
Manousaki D, Harroud A, Mitchell RE, Ross S, Forgetta V, Timpson NJ, Smith GD, Polychronakos C, Richards JB. Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study. PLOS Medicine. 2021; 18(2):e1003536.
Harroud A, Manousaki D, Butler-Laporte G, Mitchell RE, Davey Smith G, Richards JB, Baranzini SE. The relative contributions of obesity, vitamin D, leptin and adiponectin to multiple sclerosis risk: a Mendelian randomization mediation analysis. Multiple Sclerosis Journal. 2021; 27(13):1994-2000.
Harroud A, Marrie RA, Fitzgerald KC, Salter A, Lu Y, Patel M, Kowalec K. Mendelian randomization provides no evidence of a causal role in the bidirectional relationship between depression and multiple sclerosis. Multiple Sclerosis Journal. 2021; 27(13):2077-2084.
2020
Harroud A, Richards JB, Baranzini SE. Mendelian randomization study shows no causal effects of serum urate levels on the risk of multiple sclerosis. Neurology: Neuroimmunology & Neuroinflammation. 2020; 8(1):e920.
Mitchell RE, Bates K, Wootton RE, Harroud A, Richards JB, Davey Smith G, Munafo M. Little evidence for an effect of smoking on multiple sclerosis risk: A Mendelian Randomization study. PLOS Biology. 2020;18(11):e3000973.
Butler-Laporte, Kreuzer D, Nakanishi T, Harroud A, Forgetta V, Richards JB. Genetic determinants of antibody-mediated immune responses to infectious diseases agents: a genome-wide and HLA association study. Open Forum Infectious Diseases. 2020;7(11):ofaa450.
Butler-Laporte G, Harroud A, Forgetta Vincenzo, Richards JB. Elevated body mass index is associated with an increased risk of infectious disease admissions and mortality: a Mendelian randomization study. Clinical Microbiology and Infection. 2020;S1198-743X(20)30356-6.
Manousaki D, Mitchell R, Dudding T, Haworth S, Harroud A, Forgetta V, Shah RL, Luan J, Landenberg C, Timpson NJ, Richards JB. Genome-wide association study for vitamin D levels reveals 69 independent loci. American Journal of Human Genetics. 2020;106(3):327-337
2019
Harroud A, Almutlaq A, Pellerin D, Paz D, Linnell GJ, Gendron D. West Nile Virus-associated vasculitis and intracranial hemorrhage. Neurology Neuroimmunology & Neuroinflammation. 2019;7(1).
Harroud A, Morris J, Forgetta V, Mitchell R, Smith GD, Sawcer S, Richards JB. Effect of age at puberty on risk of multiple sclerosis: A Mendelian randomization study. Neurology. 2019;92:1-8.
2018
Harroud A, Richards JB. Mendelian randomization in multiple sclerosis: a causal role for vitamin D and obesity? Multiple Sclerosis Journal. 2018;24(1):80-85.
Jewett L, Harroud A, Hill MD, Cote R, Wein T, Smith EE, Gubitz G, Demchuk AM, Sahlas DJ, Lindsay P. Secondary stroke prevention care services in Canada: resources, capacity, and geographic access. CMAJ Open. 2018;6(1):E95:E102.